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Noble was elected a Fellow of the Royal Society (FRS) in 2017. She was appointed Order of the British Empire (OBE) in the 2013 Birthday Honours, elected a Fellow of the Royal Academy of Engineering (FREng) in 2008 and a Fellow of the Institution of Engineering and Technology (FIET) in 2001.

She is a trustee of the Oxford Trust, a charity established by the founders of Oxford Instruments to encourage the study, application and communication of science, technology, engineering, and mathematics. She is also a trustee of the Institution of Engineering and Technology and served as President of the Medical Image Computing and Computer-Assisted Interventions (MICCAI) Society from 2013 to 2016. As of 2017, Noble is an Honorary Fellow of Oriel College, Oxford and is a MICCAI Society Fellow. She was the first recipient of the Laura Bassi Award of the International Federation of Medical and Biological Engineering in 2015. Previously she was a Fellow of Wolfson College, Oxford from 2005 to 2011. In 2018 she presented the Woolmer Lecture.

Noble started her career as a research scientist at the General Electric Corporate R&D Center in Schenectady, New York where she worked from 1989 to 1994 on developing inspection systems for aircraft engines. She returned to the University of Oxford as a lecturer in 1995 to work on medical applications of computer vision and was promoted to Professor in 2001, as the first female Statutory Professor in Engineering at Oxford.

Noble was educated at Maidstone Grammar School for Girls in Kent and was an undergraduate student at St Hugh's College, Oxford where she was awarded a first class Bachelor of Arts degree in Engineering Science in 1986 followed by a Doctor of Philosophy degree in 1989 for research on computer vision and image segmentation supervised by Mike Brady.

Noble was a coxswain for the Oxford University Women's Lightweight Rowing Club in the Henley Boat Races in 1985.

(Julia) Alison Noble OBE FRS FREng FIET (born January 1965 in Nottingham) is Technikos professor of Biomedical Engineering at the University of Oxford, a Fellow of St Hilda's College, Oxford and Associate Head of the Mathematical, Physical and Life Sciences Division at the university. As of 2017 she is chief technology officer(CTO) of Intelligent Ultrasound Limited an Oxford University spin-off in medical imaging which she cofounded. She was director of the Oxford Institute of Biomedical Engineering (IBME) from 2012 to 2016.