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In April 2020, Witty began a leave of absence from Optum to assist the World Health Organization in developing a vaccination for COVID-19.

In November 2015 Witty's leadership of GSK was criticised by Neil Woodford, who said that "he’s not doing a very good job". Woodford called for GSK to be split into four companies. In March 2016 Witty announced that he was to stand down as chief executive. He has since become CEO of Optum, a healthcare business.

In October 2012 it was announced that he had been appointed the Chancellor of the University of Nottingham with effect from 1 January 2013, having maintained strong ties with the university since graduation. Witty announced his retirement from the role of Chancellor in November 2017.

In July 2013, the People's Republic of China announced that they were investigating allegations of fraud perpetrated by GSK going back to 2007 and involving thousands of millions of renminbi. Four GSK executives have already been arrested in China. It is alleged that the money was used, inter alia, to bribe around 25 travel agencies that organize conferences for doctors, in order to encourage the agencies to host GSK events. Witty later claimed that he knew nothing about the China fraud and tried to pass the blame onto subordinates.

On 2 July 2012, GSK pleaded guilty to criminal charges and agreed to a $3 billion settlement of the largest health-care fraud case in the U.S. and the largest payment by a drug company. The settlement is related to the company's illegal promotion of prescription drugs, its failure to report safety data, bribing doctors, and promoting medicines for uses for which they were not licensed. The drugs involved were Paxil, Wellbutrin, Advair, Lamictal, and Zofran for off-label, non-covered uses. Those and the drugs Imitrex, Lotronex, Flovent, and Valtrex were involved in the alleged bribery scheme.

Witty was knighted in the 2012 New Year Honours for services to the economy and the UK pharmaceutical industry. He was also conferred the Honorary Citizen of Singapore in 2018.

In February 2009 he pledged to make a major change in the way GSK pharmaceuticals are priced, in an attempt to make vital drugs more affordable in countries with the lowest incomes. At the same time he announced that GSK would place certain patents in a pool so that they were freely available for others in the search for new drugs.

Witty is a keen marathon runner, and ran the London Marathon in 2008. He lives in Buckinghamshire with his wife, Caroline, and two children.

He was appointed president, Pharmaceuticals Europe of GlaxoSmithKline plc in January 2003 and succeeded Jean-Pierre Garnier as CEO following his retirement in May 2008. He is paid an annual salary of GB£948,000 and receives bonuses and other compensation amounting to GB£2,180,000 for this role.

He served as a vice president and general manager of marketing of Glaxo Wellcome Inc., a subsidiary of GlaxoSmithKline with responsibility for strategy development, marketing execution and new product positioning. He served as an economic adviser to the Governor of Guangzhou, China from 2000-02.

Witty joined Glaxo UK in 1985 as a management trainee. He held various positions in the UK, including Director of Pharmacy & Distribution in Glaxo Pharmaceuticals UK.

Sir Andrew Philip Witty (born 22 August 1964) is a British business executive, who was the chief executive officer (CEO) of GlaxoSmithKline between 2008 and 2017. Witty was succeeded by Emma Walmsley on 1 April 2017. He formerly held the role of Chancellor of the University of Nottingham.