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Vargas was affiliated with Blistered Thumbs of the media production company Channel Awesome until April 2018. This was due to the then-ongoing controversy at the time regarding Channel Awesome and many of its former producers, many of whom Vargas had previously known and affiliated with in the past.

In April 2018, a Kickstarter project to create a miniatures game using licensed characters from the Street Fighter series of video games was launched by Vargas. The project's Kickstarter campaign raised $400,000 on its first day, an event which in turn attracted media coverage.

Vargas launched his YouTube channel The Angry Joe Show in October 2008 with the video "Shit that Pisses Me Off - Madden 2009 Hardcore Gamers" on October 4. The show features Vargas's character "Angry Joe" reviewing a video game on a scale of 1-10 using sketch comedy. The channel was well received by the YouTube community; as of December 2018 the channel has accrued over 900 million views and has amassed 3,000,000 subscribers. In addition to game reviews, Vargas produces movie reviews on his channel. Vargas and his channel have received mention in media covering YouTube, most notably for Vargas's opposition to copyright overreach on YouTube. Vargas's interest in copyright on YouTube stemmed from an incident in which Nintendo of America filed a copyright claim on a video of Joe playing Mario Party 10.

Jose Antonio "Joe" Vargas (born June 18, 1984) is an American media commentator and YouTuber. He is notable for his portrayal of the character "Angry Joe" and for his production of The Angry Joe Show, a video game and movie review channel.