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Lerner's fifth book, The Good Doctor: A Father, a Son, and the Evolution of Medical Ethics, was published in May 2014. It tells the true story of two doctors, a father and son, who practiced in very different times and the evolution of the ethics, paternalism, and patient autonomy that profoundly influenced health care. The son and father here are Lerner and his father, Phillip I. Lerner. The New York Times reviewed the book in July 2014, saying, "The Good Doctor is more than a son’s search to understand his father’s actions. It raises pointed questions about his own. Was his father just part of an older generation whose ideas had lost their relevance? Or did the son need to revisit ethical norms he had embraced and taught to thousands of trainees? As he asks, 'Did physicians of my father’s era actually know their patients in a different — and better — way than physicians do today?'"

Among Lerner's many contributions to The New York Times is an August, 2011 op-ed piece entitled, "The Annals of Extreme Surgery". It expressed concern over the increasing use of the HIPEC procedure, a controversial treatment for certain cancers.

His book The Breast Cancer Wars: Hope, Fear and the Pursuit of a Cure in Twentieth-Century America, published in 2001, was cited as an American Library Association Notable Book the following year. Lerner also received the 2006 William H. Welch Medal of the American Association for the History of Medicine for the book; one such Medal is awarded each year to the author or authors of a book of "outstanding scholarly merit in the field of medical history" published during the five calendar years preceding the award.

Two of Lerner's other books are Contagion and Confinement: Controlling Tuberculosis on the Skid Road (1998) and When Illness Goes Public: Celebrity Patients and How We Look at Medicine (2006).

Barron H. Lerner is a member of the faculty at the New York University Langone School of Medicine. He received his M.D. from Columbia in 1986 and his Ph.D. in history from the University of Washington in 1996. In addition to his research, Lerner practices internal medicine and teaches medical ethics and the history of medicine.

After his 9-year-old nephew Cooper Stock was struck and killed by a taxi in New York City when he had the right of way, Lerner wrote a piece for the New York Times blog entitled "Treat Reckless Driving Like Drunk Driving." In it, he notes that reckless driving "is poorly defined in the law, sometimes poorly investigated by police and almost never results in a criminal charge," much like drunk driving was treated in the 1980s. He calls to "make destruction caused by irresponsible driving a true crime."

Lerner was born to infectious disease doctor Phillip I. Lerner and teacher Ronnie Lerner (née Hober) in Boston, Massachusetts and was raised in Cleveland, Ohio. He graduated from Hawken School in 1978, from the University of Pennsylvania in 1982, and from Columbia University's medical school in 1986.

His book One for the Road: Drunk Driving Since 1900, is the first history of drunk driving in America. It was published by Johns Hopkins University Press in October 2011.