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In February 2018, Souza appeared on Mexican journalist Carmen Aristegui's show and revealed that she had been a victim of sexual assault. Souza stated that, when she was 22, she was raped by the director of a TV show she was working in; she did not name her attacker.

Souza gave a TEDx talk in León, Guanajuato, on March 21, 2015, titled "Sweet are the Fruits of Adversity". It became the most-seen Spanish TEDx talk with more than a million views.

In December 2013, Souza became engaged to Marshall Trenkmann and the couple married in May 2014. Together they have a daughter, Gianna, who was born in 2018. In May 2020, Souza announced her second pregnancy via Instagram.

Souza had her television debut in 2009 on the Mexican telenovela Verano de amor. She later starred in Mexican sitcoms Los Héroes del Norte and La Clinica. Her film roles include From Prada to Nada; in 2013, she was also in two Mexican box office hits, Nosotros los Nobles and Instructions Not Included. In 2014, Souza moved to Los Angeles to pursue English-language film and television roles. She was cast as a series regular in the Shonda Rhimes-produced legal drama series How to Get Away with Murder as law student Laurel Castillo, opposite Viola Davis. In February 2015, Souza appeared on the cover of Women's Health.

Souza first studied acting at Centro de Educación Artística, an acting school run by Televisa, in Mexico City. She also attended acting school in France and was part of a professional theatre company that toured throughout that country. While still in France, Souza auditioned and was selected to participate in the French reality TV show Star Academy, however, she turned down the offer after receiving an invitation to study at London's Central School of Speech and Drama. She graduated from the school in 2008 with a Bachelor of Arts in acting. Near the end of her London studies, she received a CCP award, traditionally presented to the most promising actress in London. After being selected to go to Moscow with Anatoly Smilianski for an acting intensive, she returned to Mexico City and began acting in television and film when she was 22.

Karla Susana Olivares Souza (born December 11, 1985) is a Mexican actress. She is known for her role as Laurel Castillo on the ABC legal drama series, How to Get Away with Murder.

Souza was born in Mexico City on December 11, 1985, to a Chilean father and a Mexican mother, Mónica. Her grandmother, Elba Silva, was an assistant cook for the Rockefeller family for twenty years after immigrating to New York City from Chile in the 1960s. Having lived in Aspen, Colorado, until she was eight years old, Souza credits her grandmother's immigration to the United States as the reason she has an American passport.