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Goble was appointed Commander of the Order of the British Empire (CBE) in the 2014 New Year Honours for services to science.

She was appointed to the Biotechnology and Biological Sciences Research Council on 13 June 2013.

She was elected a Fellow of the Royal Academy of Engineering (FREng) in 2010. In January 2018 Goble was awarded the degree of Doctorem (Honoris Causa) by Maastricht University.

Goble was recipient of the first Jim Gray e-Science Award in December 2008. Tony Hey, corporate vice-president of Microsoft External Research who sponsored the award, said Goble was chosen for the award because of her work to help scientists do data-intensive science through the Taverna workbench.

Her work has won best paper awards at the 3rd IEEE International Conference on e-Science and Grid Computing (2007) and the 11th ACM International Conference on Hypertext. In 2002 she was honoured by Sun Microsystems for her significant achievements in advancing Life Science Computing. She has given keynotes in many forums, including international conferences on: Digital curation, e-Social Science, Grid Computing, Intelligent Systems for Molecular Biology, Pacific Symposium on Biocomputing, Hypertext and Hypermedia, Bioinformatics Open Source Conference (BOSC), Artificial intelligence, Systems Biology, Discovery Science, the Semantic Web, International World Wide Web Conference and Medical Informatics.

Goble joined the University of Manchester in 1985, and was appointed to a chair in 2000. She is an editorial board member of IEEE Internet Computing, GigaScience, and the International Journal of Web Service Research, and used to be the Editor-in-chief of Elsevier's Journal of Web Semantics.

Goble was educated at Maidstone Grammar School for Girls. Her academic career has been spent at the Department of Computer Science where she gained her Bachelor of Science degree in computing and information systems from 1979 to 1982.

Carole Anne Goble, CBE FREng (born 10 April 1961) is a Professor of Computer Science at the University of Manchester. She is principal investigator (PI) of the myGrid, BioCatalogue and myExperiment projects and co-leads the Information Management Group (IMG) with Norman Paton.