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Koepsell's research interests have focused on the nexus of ethics, law, and science. Specifically, while at Yale as a Visiting Fellow (2006–2007), he investigated ethical questions involved in the practice of bioprospecting and patenting elements of the human genome. Koepsell argues that there are two forms of commons, fiat and natural, otherwise called "commons by choice" and "commons by logical necessity." He has recently argued that DNA, like radio spectra, sunlight, and air, falls into the category "commons by logical necessity", and that attempts to own genes by patent are unjust. His book on the subject, entitled Who Owns You, was published by Wiley-Blackwell in March 2009. While it was endorsed by Nobel Prize winner John Sulston as a "lucid and compelling deconstruction of current practice in the patenting of human genes, exposing inherent contradictions in the process and offering practical ways to resolve them", a starkly contrasting review of Who Owns You? has also been published. In an interview for Singularity University, he applauded the court decision in the Myriad Genetics case that "a naturally occurring DNA segment is a product of nature and not patent eligible merely because it has been isolated", while manipulation of a gene to create something not found in nature could still be eligible for patent protection.

Koepsell earned his PhD in philosophy (1997) as well as his doctorate in law (1995) from the University at Buffalo, where he studied with Barry Smith. Koepsell currently serves as an adjunct professor in the Department of Learning and Instruction, the University at Buffalo. He has lectured worldwide on issues ranging from civil rights, philosophy, science, ontology, intellectual property theory, society, and religion. Koepsell was appointed assistant professor of philosophy at TU Delft in September 2008 and was promoted to associate professor in September 2013. He is an associate editor of Free Inquiry magazine. He is the co-founder, with Edward Summer, of Carefully Considered Productions, an educational media not-for-profit corporation. He is also the co-founder of Encrypgen. Koepsell also serves on the advisory board of the Center for the Study of Innovative Freedom..He joined the software startup spin-off from ConsenSys, ConsenSys Health as General Counsel and Chief Ethics & Compliance Officer in March, 2020.

David R. Koepsell (born 1969) is an American author, philosopher, attorney, and educator whose recent research focuses on how ethics and public policy deal with emerging science and technology. He has been a practicing attorney, been employed as an ontologist, been a university professor, and has lectured worldwide. He is a visiting professor of research ethics at National Autonomous University of Mexico, director of research and strategic initiatives at Comisión Nacional de Bioética (CONBIOETICA) Mexico, an adjunct professor at University at Buffalo and a senior fellow and education director of the Center for Inquiry Transnational, based in Amherst, New York.