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As of January 2018, Grimes had worked with Centre for Advanced and Interdisciplinary Radiation Research (CAIRR), and the School of Mathematics and Physics, Queen’s University Belfast, in Belfast, United Kingdom.

He has a number of other research interests, including with regard to dubious beliefs in general; a 2016 research analysis of common scientific conspiracy claims was performed using a Poisson statistical framework. The work suggests that massive conspiracies should quickly collapse, and was widely covered in the media. His writing includes consideration of dubious medical practices, including a 2012 review piece critical of homoeopathic claims, presented from a physics perspective.

Grimes has been particularly vocal against the anti-vaccine movement, focusing on assertions by anti-HPV vaccine groups whose arguments, Grimes says, consist of "anecdotes, emotive appeals and easily debunked assertions", opining that "lives of countless young men and women count on us being guided by evidence rather than rhetoric." In 2016, following controversy around the film Vaxxed, Grimes was drawn into a debate with former doctor Andrew Wakefield on Irish radio. Grimes later wrote of his reluctance to take part in the debate, and how providing Wakefield with any platform is false balance. He was extremely critical of the decision by Regent's University to host Wakefield, explaining that "Wakefield is a long-debunked fear merchant."

He is also the author of a 2014 research study on the physics of string-bending that occurs during electric guitar playing, which was covered extensively in the media.

In recognition of his efforts to present science despite hostility, Grimes was joint recipient of the 2014 Sense About Science / Nature Maddox Prize for standing up for science in the face of adversary, and was commended by Cancer Research UK for being "... an excellent media ambassador for CRUK, and for his efforts to dispel misconceptions in science and medicine". In 2015, he was also inducted into the Dublin City University Alumni Wall for his research and outreach work.

Grimes has been critical of anti-fluoride campaigns, in particular a 2013 Sinn Féin bill to ban fluoride in water. This stance made him the target of conspiracy theorists, and prompted a campaign to have him removed from his university post. The bill was ultimately defeated.

Grimes has drawn attention to charlatans who take advantage of vulnerable people using pseudoscience, particularly autistic people and cancer sufferers. Equally, he has been vocal about crowdfunding for dubious medical conditions and clinics, such as the Burzynkski clinic in Texas, US, stating that while emotive, "... raising money for such causes does not help sufferers one iota – it benefits only those with the audacity to push false hope at great expense.".

Grimes did doctoral work on ultraviolet radiation physics at Dublin City University funded by an Irish Research Council award, under Neil O'Hare and Greg Hughes, and graduated with a Ph.D. in 2011. He did a postdoctoral fellowship at the University of Oxford with Mike Partridge, and focused on medical physics and oncology, including a 2015 research work on oxygen-radiation interactions (the "oxygen fixation hypothesis and oxygen enhancement ratio")—about which he blogged—and literature reviews on modelling tumour oxygen distribution and hypoxia in 2014 (which received media attention), and on non-invasive imaging in 2017.

David Robert Grimes (born 1985) is an Irish science writer with professional training in physics and cancer biology, who contributes to several media outlets on questions of science and society. He has a diverse range of research interests, and is a vocal advocate for increased public understanding of science. He was the 2014 recipient of the Sense About Science/Nature Maddox Prize for "Standing up for Science in the face of Adversity".

David Robert Grimes, from a Skerries family, was born in Dublin in 1985. Grimes spent over a decade in Riyadh, Saudi Arabia. As a student he was a keen musician and actor, with an interest in science. He undertook his undergraduate degree in applied physics at DCU, serving on the Student Union as faculty-wide Science and Health Convenor 2005–2006, and on the DCU drama committee, graduating in 2007 with a DCU Internal School Award, the Lyman Medal for physics.