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In January 2019, HIGH: Everything You Want to Know About Drugs, Alcohol, and Addiction, was published. A resource for middle-school readers offering clear, direct information about the realities of drugs and alcohol, it is Sheff and his son Nic's first collaborative project.

In 2019, Sheff founded The Beautiful Boy Fund, a charity devoted to making quality, evidence-based treatment for substance-use disorder accessible to those in need of treatment, and identifying and supporting research to further the field of addiction medicine.

In 2018, Felix van Groeningen adapted Sheff's book Beautiful Boy into a feature film of the same name. In the film, Sheff is portrayed by Steve Carell, with Timothée Chalamet as his son, Nic. Actress Maura Tierney portrays David's wife, artist Karen Barbour, and Amy Ryan plays Nic's mother, Vicki. This is what viewers called Steve Carell and Amy Ryan's first time acting together since their romantic duo as Michael Scott and Holly Flax on The Office U.S.

David Sheff (born 1955) is an American author of the books Beautiful Boy: A Father's Journey Through His Son's Addiction, Clean: Overcoming Addiction and Ending America's Greatest Tragedy and All We Are Saying: The Last Interview with John Lennon and Yoko Ono. In 2009, Sheff was included in Time Magazine' s Time 100, The World's Most Influential People, and Beautiful Boy was named the best nonfiction book of the year by Entertainment Weekly. The book also won the Barnes & Noble "Discover Great New Writers Award" for nonfiction and was an Amazon Best Book of the Year (2008). He received media awards from College of Problems on Drug Dependence (CPDD), American Society of Addiction Medicine, The Partnership for Drug-free Kids, College of Problems on Drug Dependence (CPDD), American College of Neuropsychopharmacology (ACNP), American Society of Addiction Medicine (ASAM), and was the first recipient of the American Academy of Addiction Psychiatry (AAAP) Arts and Literature Award.