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In 2018 a five-part television series, Patrick Melrose was broadcast, a joint production of Showtime and Sky Atlantic. Benedict Cumberbatch stars as Patrick Melrose (with the young Patrick played by Sebastian Maltz), with each episode based on a different novel in the series. The series premiered on Showtime on 12 May 2018 to favourable reviews.

Five of St Aubyn's novels, Never Mind, Bad News, Some Hope, Mother's Milk, and At Last, form The Patrick Melrose Novels, the first four of which were republished in a single volume in 2012, in anticipation of the fifth. They are based on the author's own life, growing up in a highly dysfunctional upper-class English family, dealing with abuse at the hands of his father, the deaths of both parents, alcoholism, heroin addiction and recovery, and marriage and parenthood.

Mother's Milk was made into a feature film released in 2011. The screenplay was written by St Aubyn and director Gerald Fox. It stars Jack Davenport, Adrian Dunbar, Diana Quick, and Margaret Tyzack in her last performance.

From 1987 to 1990, he was married to the author Nicola Shulman, now The Marchioness of Normanby. St Aubyn has two children, and lives in London.

St Aubyn attended Westminster School and in 1979 went on to read English at Keble College, Oxford. Athough at the time a heroin addict, he graduated with a pass, the lowest possible class of degree. He entered psychotherapy at the age of 25 and subsequently became a professional writer.

Edward St Aubyn (born 14 January 1960) is an English author and journalist. He is the author of eight novels, including notably the semi-autobiographical Patrick Melrose novels. In 2006, Mother's Milk was shortlisted for the Booker Prize.

Edward St Aubyn was born in 1960 in London, England, into an upper-class family. He is the son of Roger Geoffrey St Aubyn (1906–1985), a former soldier and a surgeon, and his second wife, Lorna Mackintosh (1929–2005). On his paternal side, he is great-great grandson of Sir Edward St Aubyn, 1st Baronet, and great-nephew of The 1st Baron St Levan. On his maternal side, he is grandson of Captain Alastair William Mackintosh of the Seaforth Highlanders (briefly married to Constance Talmadge 1926–1927), and Lela Emery (later Duchess of Talleyrand). Through the latter he is great-grandson of American businessman John Josiah Emery, Sr., and great-nepew of John J. Emery, Jr. and Audrey Emery (wife of Grand Duke Dmitri Pavlovich of Russia).

His father was first married to Sophie Helene Freifrau von Puthon of Schloss Mirabell in Salzburg, whom he divorced in 1957. St Aubyn has two half-sisters by his father's first marriage, and an elder sister, Alexandra. He grew up in London and France, where his family had houses. He has described an unhappy childhood in which he was repeatedly raped by his sexually abusive father from the ages of 5 to 8, with the complicity of his mother.