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Powrie studied biochemistry at the University of Bath, before completing a D. Phil. in Don Mason’s lab at the Sir William Dunn School of Pathology, the University of Oxford.

In 2009, Powrie was appointed as the inaugural Sidney Truelove Professor of Gastroenterology within the Nuffield Department of Clinical Medicine in Oxford. She was elected a Fellow of the Royal Society in 2011, and was awarded the Louis-Jeantet Prize for Medicine in 2012.

Powrie performed post-doctoral studies with Robert L. Coffman at DNAX in Palo Alto, California. Here, she extended her earlier work in rats to mice and developed the “T cell transfer” model, one of the most prominent models of intestinal inflammation where transfer of CD4+CD45RBhi T cells to Rag deficient or SCID mice led to the development of severe intestinal inflammation and wasting disease. This could be prevented by transfer of CD4+CD45RBlo T cells. Using this model Powrie further identified the pathogenic role played by IFN-γ and TNF-α in intestinal inflammation and the therapeutic potential of IL-10 and highlighted the requirement for TGF-β in the prevention of colitis by the CD4+CD45RBlo regulatory T cell subset Upon returning to the University of Oxford in 1996, first to the Nuffield Department of Surgery and later, the Sir William Dunn School of Pathology, Powrie used the T cell transfer model to identify the suppressive mechanisms used by regulatory T cells to prevent intestinal inflammation including the requirements for CTLA-4 and the capacity of Treg to prevent colitis driven by innate immune cells as well as CD4+ T cells. Focusing on pathogenic mechanisms the Powrie lab. identified the critical role played by the cytokine IL-23 in driving pathology in the intestine

Fiona Magaret Powrie (born 1963) FRS FMedSci is currently the head of the Kennedy Institute of Rheumatology at the University of Oxford. Formerly she was the inaugural Sidney Truelove Professor of Gastroenterology at the University of Oxford. She is also head of the Experimental Medicine Division of the Nuffield Department of Clinical Medicine.