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Stotz introduced the concept of Developmental Niche Construction as an integrative framework for the study of various non-genetic (exogenetic) inheritance mechanisms and for an explanation of how the environment (physical, biological or social) can construct new heritable variations during individual development. This concept originated in the idea of the ‘ontogenetic niche’ introduced in 1987 by developmental psychobiologists Meredith West and Andrew King, and theory of 'niche construction' presented by biologist John Odling-Smee in 1988. Stotz juxtaposes Developmental Niche Construction with Niche Constriction Theory and its concept of the ‘Selective Niche’ that stresses the role of selection in evolution rather than the production of new variation in developmental systems. She reconstructs the developmental system of DST as the Organism-Developmental Niche System. It informs the Developmental Systems Account of Human Nature developed together with Paul Griffiths.

Stotz was born in Neumünster in Schleswig-Holstein. She received her Magister Artium in Biology and Social Sciences (Anthropology) in 1993 (University of Mainz) and her PhD in Philosophy from the University of Ghent, Belgium, in 1999 under the supervision of Gertrudis Van de Vijver and Werner Callebaut. In the period between 1999-2007 she worked at different universities of Australia and the United States of America. From 2008 until 2013, Stotz was Australian Research Fellow and, later, Bridging Support Fellow at the Department of Philosophy, University of Sydney. In 2014 she received the position of Senior Lecturer at the Department of Philosophy, Macquarie University, Australia. From 2014 to 2017, with her partner Paul Griffiths, Stotz worked on a Templeton World Charity Foundation project entitled: "Causal Foundations of Biological Information".

Karola Stotz (September 8, 1963 – October 14, 2019) was a German scholar of philosophy of biology, cognitive science, and philosophy of science. With Paul E. Griffiths, she pioneered the use of experimental philosophy methods in the field of philosophy of science.