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In November 2019, Lane Fox was named by media and marketing publication The Drum, in association with the Futures Network, Innovate Her and WACL, as the most influential woman in Britain's digital sector from the past quarter of a century.

In 2017, Lane Fox was appointed a member of the Joint Committee on National Security Strategy. In 2018 she was appointed Non Executive Director of Chanel as well as Donmar Warehouse and a Trustee of the Queens Commonwealth Trust. Lane Fox continues to be a Patron of AbilityNet, Reprieve, Camfed and Just for Kids Law. She joined the board of social network Twitter in June 2016.

Lane-Fox lives in Marylebone, London, with her partner Chris Gorell Barnes. Their identical twin sons, Milo and Felix, were born in 2016. In May 2004 she was severely injured in a car accident in the tourist resort of Essaouira in Morocco and was flown to England for treatment at John Radcliffe Hospital, Oxford, and later Wellington Hospital in London. She was discharged from hospital in December 2005.

She entered the House of Lords as a crossbencher on 26 March 2013, becoming its youngest female member, and was appointed Chancellor of the Open University on 12 March 2014. In November 2019, Lane Fox was named as the most influential woman in Britain's digital sector from the past quarter of a century..

She entered the House of Lords as a crossbencher on 26 March 2013, becoming its youngest female member. In her maiden speech, she addressed the need for digital literacy in all sectors of the economy. That same year the Open University appointed her Chancellor. In the run-up to the Scottish independence referendum of 2014, Lane Fox signed an open letter opposing Scottish independence.

Lane Fox was appointed Commander of The Most Excellent Order of the British Empire (CBE) in the 2013 New Year Honours for "services to the digital economy and charity". In February 2013 she was assessed as one of the 100 most powerful women in the United Kingdom by Woman's Hour on BBC Radio 4. In the same month it was announced that she was to be created a life peer to sit as a crossbencher in the House of Lords.

On 25 March 2013, she was raised to the peerage as Baroness Lane-Fox of Soho, of Soho in the City of Westminster, and was introduced in the House of Lords the next day. On 29 October 2015, Lane Fox was ranked 15th on the Richtopia list of 100 Most Influential British Entrepreneurs. In February 2016, Lane Fox was elected a Distinguished Fellow of BCS, The Chartered Institute for IT, after being nominated by The Duke of Kent.

From 2009 to 2013 she was Digital Champion for the UK and helped to create the Government Digital Service – this team launched gov.uk, and was tasked with spearheading a two-year campaign to improve computer literacy. The following year she was assigned to establish the Digital Public Services Unit within the Cabinet Office. and invited to sit on the Cabinet Office Efficiency and Reform Board. The following month Lane Fox was honoured by David Cameron for her "Manifesto for a Networked Nation", a challenge to increase British internet engagement. She resigned from her position as Digital Champion in late 2013.

Following her departure from Last Minute, Lane Fox was tapped to take over day-to-day operations at Selfridges but was involved in an auto accident before she could assume that role. At the suggestion of advertising executive Julian Douglas, Fox teamed up with Nick Thistleton to launch karaoke company Lucky Voice, which owns seven bars, including a club in Soho and revolutionised the karaoke industry. In 2007, Lane Fox joined the board of Marks & Spencer.

Lane Fox is an advocate for such causes as human rights, women's rights, and social justice. In 2007 she founded Antigone, a grant-making trust to support charities based in the United Kingdom. She is a patron of Reprieve, a legal action charity notable for its involvement in the release of UK resident Binyam Mohammed from Guantanamo Bay, and Camfed, an organization dedicated to fighting poverty, HIV, and AIDS in rural Africa through an emphasis on education of young women. She is also patron of the charity Just for Kids Law, which supports children and young people in London, as well as fighting for wider reform on behalf of young people across the UK.

Lane Fox showed interest in acting and prison governorship but instead joined information technology and media consulting firm Spectrum, where she met Brent Hoberman. In 1998, Lane Fox and Hoberman founded Last Minute, an online travel and gift business that generated significant publicity, floating at the peak of the dot-com bubble. She stepped down as managing director in 2003. Meanwhile, the company survived the dot-com crash to be bought out by Sabre Holdings in 2005 for £577m.

Martha Lane Fox, Baroness Lane-Fox of Soho, CBE (born 10 February 1973) is a British businesswoman, philanthropist and public servant. She co-founded Last Minute during the dotcom boom of the early 2000s and has subsequently served on public service digital projects. She sits on the boards of Twitter, Donmar Warehouse and Chanel, as well as being a trustee of The Queens Commonwealth Trust. She previously served on the board of Channel 4.