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Marcasiano has designed costumes for DanceBrazil, the New York City Ballet, RythMEK at Jacob’s Pillow, Cleo Parker Robinson Dance, Michael Thomas Lab and for the short film “ Até Quando“. In 2009 Marcasiano collaborated with renowned artist Eric Fischl on costumes for his suite of sculptures titled “ Ten Breaths “ which was exhibited in Germany, Paris and New York. Marcasiano designed the costumes for the 2010/2011 world tour of Grammy award-winning singer Angelique Kidjo and was costume designer for the PBS Special "Angelique Kidjo and Friends: Spirit Rising". In 2013 Marcasiano designed costumes for the feature film “Reaching for the Moon” directed by Bruno Barreto.

Marcasiano also works with women's co-operatives in developing countries, particularly in Africa and South America, facilitating the sale and distribution of the products to a global market through web sales and strategic marketing alliances. The Made With Love Project directs the net proceeds received from the sale of those products to relevant children's charities in the region of the product’s origination.

In 2007 Marcasiano created the Made With Love Project, a non-profit global initiative dedicated to raising funds and awareness for NGOs aiding women and children in need. The project is supported through the production and sale of products that provide a fair income for women in Brazil, Africa and Haiti. Made With Love does their works through the Cygnet Foundation, a 501(c)(3) non-for-profit public foundation.

In 2002, Marcasiano produced “Ginga”, a documentary film about Capoeira directed by Gustavo Moraes. She currently serves as Director of Development and Special Events Advisor to Cinema Tropical, a non-profit foundation that distributes and promotes Latin American cinema in the United States. She was the programmer for Cinema Tropical’s Music+Film series at 92YTribeca and directed their Brazilian film initiative Janeiro in New York.

Marcasiano's business was purchased by Hampshire Designs in 1995 and was later acquired by Marisa Christina in 1998.

While attending Parsons, Marcasiano moved to the Soho area of Manhattan, a neighborhood that played an important role in her creative development and business approach. Recognized as one of the young downtown emerging designers she showed her first collection in 1979 at the Susan Caldwell Gallery in SoHo. In the early ‘80s Marcasiano became a member of the Council of Fashion Designers of America and was the awarded the Cartier, DuPont, Cutty Sark and Wool Knit Awards.

Marcasiano formed her eponymous company in 1979 with her first womenswear collection and introduced a menswear line in 1980. In 1985 she licensed her name to shoes, furs and jewelry produced in Italy.

Mary Jane Marcasiano (born September 23, 1955) is an American fashion and costume designer, film producer, and social entrepreneur.