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Scherzer started for the Nationals on Opening Day 2019 against Jacob deGrom of the Mets at Nationals Park.

In 2019 he was 11-7 with a 2.92 ERA. He led all major league pitchers in strikeouts/walks, at 7.364.

Prior to the 2018 season, Sports Illustrated graded Scherzer as the top pitcher, and fourth-best overall player in baseball, following Trout, José Altuve, and Kris Bryant. In his first 98 starts with the Nationals from 2015–17, Scherzer accumulated the most innings, strikeouts, and pitching WAR. He initiated a contest with at least five hitless innings 11 times, including successfully concluding two no-hitters. He made his third Opening Day start for Washington and struck out seven consecutive Cincinnati Reds batters on the way to a 2−0 win. His ten batters struck out overall set a club Opening Day record. While playing Atlanta on April 9, he stole his first career base in the seventh inning, versus pitcher Peter Moylan and catcher Kurt Suzuki. On the mound, Scherzer gained a complete game shutout, the fifth of his career. He struck out 10 and allowed two hits and no walks. He earned the NL Pitcher of the Month Award in April while leading the league in strikeouts (57) and wins (4), and ranking fourth in each of ERA (1.62), WHIP (0.82) and opposing batting average (.165). On May 6, Scherzer emerged as the first pitcher in major league history to produce 15 strikeouts in one game in ​6  ⁄3 innings (19 outs) or fewer, doing so versus the Philadelphia Phillies. Twelve consecutive outs occurred vía strikeout, including striking out the side in the third, fourth, and fifth innings. It was the second-longest such streak in major league history, his fifth career 15-strikeout game, and the 69th with at least 10. He made his following start versus the Arizona Diamondbacks, where he struck out 11 batters and hit an RBI double for the go-ahead run in the fourth inning that furnished a 3–1 Nationals victory. In a May 19 start versus the Dodgers, Scherzer struck out 13, including dispatching his 100th of the season in 63 innings. It eclipsed Kerry Wood's record for fewest innings to reach 100 strikeouts with ​65  ⁄3 realized in 2001. Still, the Nationals lost the game, 4–5, off a blown save by Sean Doolittle.

For the 2018 season, Scherzer was 18-7 with a 2.53 ERA. He threw 3,493 pitches, more than any other major league pitcher. He finished second in Cy Young Award voting, behind Jacob deGrom.

Scherzer has been nicknamed "Mad Max" due in part to a perceived higher-than-normal intensity during game play, and unusual and extensive preparation techniques. He also prepares intently on other aspects of the game, including hitting and baserunning. According to Nationals manager Dave Martinez, Scherzer differentiated himself from other major league pitchers because of his focus on hitting in addition to the work on his pitching. As of August 6, 2018, his batting average as a pitcher (.283) on the season was second-best at his position in the National League to Germán Márquez (.350).

Having sustained a stress fracture in a knuckle of his right ring finger prior to the 2017 season, Scherzer was unavailable to start Opening Day for the Nationals. He navigated a delayed start to spring training and missed the World Baseball Classic. Nonetheless, he avoided spending any time on the disabled list to start the season. On May 14, 2017, he pitched his first career immaculate inning, striking out César Hernández, Odubel Herrera, and Aaron Altherr on nine pitches in the fourth inning versus Philadelphia. It was the 84th immaculate inning in the major leagues, and second in Nationals' history, following Zimmermann's versus the Florida Marlins in 2011. In a 2–1 win versus the Dodgers on June 6, Scherzer struck out 14. He obtained the first 10 outs of the game via strikeout in spite of his own throwing error on a pickoff attempt, two walks allowed, and a passed ball by Matt Wieters.

In 2017 he was 16-6 with a 2.51 ERA. He led the majors in giving up the lowest percentage of hard-hit balls (26.5%).

End of season awards for Scherzer included selection as a starting pitcher on Baseball America's All-MLB Team. Scherzer also won the 2017 National League Cy Young Award—his third—making him the tenth pitcher in history to win at least three. He was the Players Choice Award winner for National League Outstanding Pitcher, the second of his career. He was also elected to the Arizona Fall League Hall of Fame in late 2017, along with Mike Trout and David Wright, and had his number 51 jersey retired by the Scottsdale Scorpions. His AFL achievements included a 2.13 ERA in eight games in 2017 and a 3.38 ERA over four starts in 2008.

Scherzer was going to play for Team USA in the 2017 World Baseball Classic. However, in early January 2017 it was reported that he would not play in the tournament after suffering a stress fracture in the knuckle of his right ring finger. He was replaced by teammate Tanner Roark.

Scherzer met his future wife, Erica May, at the University of Missouri, where both were pitchers. May pitched for the Mizzou softball team before a heart condition forced her to stop playing. After more than eight years of dating, the couple married in November 2013, and have two daughters. They welcomed Brooklyn, their first daughter, on November 29, 2017. On July 4, 2019, Kacey Hart Scherzer was born. The family resides in McLean, a suburb of Washington, D.C., in Northern Virginia. They own four rescue dogs and two cats.

During his major league debut, Scherzer established the record for most consecutive hitters retired in a relief appearance as a major league debut with 13. He became the third pitcher to start a season with a 19–1 win–loss record, on the way to winning his first Cy Young Award in 2013. In 2015, Scherzer became the sixth pitcher in Major League history to record multiple no-hitters in a single season, including the first with at least 17 strikeouts and no bases on balls, and the first to accrue a game score of 100 or more twice in one season. On May 11, 2016, he tied the major league nine-inning strikeout record with 20, making him the second player to achieve both a no-hitter and 20 strikeouts over nine innings, and in the same game became the youngest-ever pitcher to beat all 30 teams. In 2017, he became the third-fastest hurler to record 2,000 strikeouts, and the fourth to strike out 250 or more in four consecutive seasons. Scherzer recorded more wins (161) and strikeouts (2,503) than any pitcher in the 2010s. He recorded one immaculate inning each in 2017 and 2018.

On May 11, 2016, Scherzer struck out 20 Detroit Tiger batters, his former team, to tie the record for strikeouts over nine innings in a single game, held by Roger Clemens (twice), Randy Johnson, and Kerry Wood. Scherzer became the first pitcher to strike out 20 batters in a regulation game in the 21st century. He accomplished the feat and earned the win in a matchup with former Nationals teammate Jordan Zimmermann; the final score was 3–2. Scherzer joined Johnson as the only pitchers to have performed both a 20 strikeout game and a no-hitter during their careers. Nine of the strikeouts ended on three-pitch at bats. Of 119 total pitches discharged, 96 were for strikes; Scherzer did not deliver more than 16 in any inning. It was the first time in history that in any game of 125 or fewer pitches delivered, 96 or more were strikes. It was the third occasion that Tiger manager Brad Ausmus was on the losing the side of a 20-strikeout game; the first two were as a player. It was also Scherzer's first career victory versus Detroit, positing him as the 17th hurler to earn a win against all 30 MLB teams.

On July 8, 2016, Scherzer was named to the National League squad at the All-Star Game in San Diego as roster replacement for teammate Stephen Strasburg, who was recently activated from the DL. Scherzer performed in relief in the sixth inning, allowing no baserunners. His aggregate season batting achievements included a career-best 12 RBI, which ranked second among major league pitchers to Adam Wainwright with 18.

Scherzer was named the National League Cy Young Award winner on November 16, 2016, winning his second Cy Young Award on the strength of a 20–7 record, 2.96 ERA, MLB-leading 284 strikeouts, and an MLB-leading 0.968 WHIP. He became just the sixth pitcher in Major League Baseball history to win the award in both the American and the National Leagues. He won two of the 2016 Esurance MLB/This Year in Baseball Awards: for Best Pitcher, and his 20-strikeout game was singled out for Best Performance.

On January 21, 2015, Scherzer agreed to a contract with the Washington Nationals, now led by Rizzo as general manager. The contract was for seven years and $210 million ($226.5 million today), and included a $50 million signing bonus to be paid out over 14 years, the largest deferral in MLB history. At the time, Scherzer owned a 91–50 W–L with a 3.58 ERA in seven seasons with Arizona and Detroit. On January 22, it was reported that the contract also specified for Scherzer's salary to be $10 million in 2015, and $15 million in each of the next three seasons. It then increases to $35 million a year in 2019, 2020 and 2021, the seasons in which his deferrals begin. In addition, his contract includes several award incentives, as well as a no-trade clause.

Scherzer made his regular season debut for the Nationals as their Opening Day starting pitcher versus the New York Mets on April 6, 2015. He struck out eight over ​7  ⁄3 innings in a 3–1 loss. On June 14, 2015, he pitched his second career complete game, ceding one hit and one walk in a 4–0 shutout against the Milwaukee Brewers at Miller Park. He accrued six perfect innings before Carlos Gómez, leading off the seventh inning, fought off a 96 miles per hour (154 km/h) fastball for a bloop single to right field inches past the outstretched glove of second baseman Anthony Rendon. Scherzer's 16 strikeouts established a new personal best and a Nationals team record for one game, surpassing Stephen Strasburg's effort of 14 versus the Pittsburgh Pirates on June 8, 2010. Rated with a game score of 100, Scherzer's was the 12th time in MLB history such a score or higher had been achieved.

Scherzer finished the 2015 season with a 2.79 ERA and 0.92 WHIP, while striking out 276 batters against only 34 walks for an MLB-leading 8.12 K:BB ratio. He also led all major league pitchers in first-strike percentage (73.3%). Despite these exceptional numbers, Scherzer was often the victim of poor hitting support, compiling only a 14–12 record.

On January 17, 2014, Scherzer and the Tigers agreed on a $15.525 million salary for the 2014 season, avoiding arbitration for the third straight year.

Scherzer finished the 2014 season with an 18–5 record, 3.19 ERA and 1.175 WHIP. New career bests prevailed, including in innings (​220  ⁄3 ) and strikeouts (252). His 18 wins tied for the AL lead along with Corey Kluber and Jered Weaver.

Max made his only postseason appearance of 2014 in Game 1 of the ALDS against the Baltimore Orioles. He was tagged with the loss after surrendering five runs (all earned) in ​7  ⁄3 innings.

Of Scherzer's three most brilliant performances that season, one tweet adduced that he "was a bloop single, an over-sized elbow pad, and a throwing error away from throwing three perfect games." That description was nearly precise; however, in the June 14 contest versus Milwaukee, Scherzer also issued a bases on ball to Scooter Gennett after allowing Gómez' single—leaving Scherzer four batters short of three perfect games. Thus, he became the first to assemble three games scores of 97 or higher in one season since at least 1914. Ryan and Walter Johnson (1918) were the only two other pitchers to carry out three game scores of 95 or more in one season. In a season that also featured mammoth offensive accomplishments from NL Most Valuable Player (MVP) Bryce Harper, the Nationals were eliminated from the playoff contention with a week remaining.

—David Price, Scherzer's teammate in Detroit

—Derek Lilliquist, Nationals pitching coach

Detroit optioned Scherzer to the Triple-A Toledo Mud Hens on May 16, replacing him with Armando Galarraga. Shortly thereafter, Scherzer was recalled to the major leagues for good, going 6–4 in twelve starts with an ERA of 2.62 and 85 strikeouts in 75​⁄3 innings.

After a win against the Tampa Bay Rays on June 28, 2013, Scherzer became the first Tigers pitcher to ever start a season 12–0, surpassing the 11–0 start from George Mullin in 1909. With a win against the Toronto Blue Jays on July 3, Scherzer also became the first major league starter to begin a season 13–0 since Roger Clemens in 1986. The streak ended with a loss to the Texas Rangers on July 13.

On July 1, Scherzer was selected by player vote to represent the American League in the 2013 All-Star Game, his first major league All-Star selection. On July 15, Jim Leyland, who managed the AL All-Star team this season and was also the Tigers manager, announced that he had chosen Scherzer as the AL's starting pitcher. Entering the All-Star break, Scherzer had a 13–1 record, 3.19 ERA, 0.98 WHIP and 152 strikeouts in ​129  ⁄3 innings pitched. He pitched a perfect 1-2-3 inning in the game, including striking out Joey Votto for one of three outs.

On August 8, Scherzer recorded his 1,000th career strikeout when he fanned Jason Kipnis of the Cleveland Indians. With a win over the New York Mets on August 24, Scherzer became the third pitcher in major league history to start a season 19–1, following Clemens in 2001 and Rube Marquard in 1912.

On September 20, after a 12–5 win over the Chicago White Sox, Scherzer became the first major league pitcher to reach 20 wins. Scherzer became the second Tigers pitcher to reach 20 wins since Bill Gullickson in 1991, following Verlander in 2011, and the 45th in Tigers history. He finished the regular season at 21–3, with a league-leading 0.97 WHIP, 2.90 ERA, and a career-high 240 strikeouts. He was the only 20-game winner in the majors in 2013. Scherzer's stellar season earned him the 2013 AL Cy Young Award, receiving 28 of 30 first-place votes. He also was the winner of the Players Choice Award for AL Outstanding Pitcher, and the Baseball Digest Pitcher of the Year—bestowed annually to one pitcher in the major leagues.

Scherzer cultivated a dominant performance in Game 1 of the 2013 ALDS versus the Oakland Athletics, recording 11 strikeouts and giving up just one hit through the first six innings, before surrendering a two-run homer to Yoenis Céspedes. He finished with seven innings pitched, giving up three hits, as he and the Tigers won the game, 3–2. He struck out each of Josh Donaldson, Brandon Moss, and Josh Reddick twice. Scherzer was in line to make a Game 5 start in the same series, but facing elimination in Game 4, manager Jim Leyland chose to bring him in as a reliever in the seventh inning. Scherzer gave up the go-ahead run in the top of the inning, but the Tigers regained the lead in the bottom of the frame. Scherzer then loaded the bases with no outs in the top of the eighth, but wriggled out of trouble by striking out Josh Reddick and Stephen Vogt, then getting Alberto Callaspo to line out to center field. The Tigers won the game, and Scherzer earned the victory to go to 2–0 in the series.

Scherzer continued his brilliance into the 2013 ALCS against the eventual World Series champion Boston Red Sox. In Game 2, he no-hit Boston for ​5  ⁄3 innings before surrendering two hits and a run in the bottom of the sixth. He left the game with a 5–1 lead after seven innings, striking out 13. However, a quartet of Tiger relievers blew the lead in the eighth inning, and Boston won it, 6–5, on a walk-off single in the ninth. Scherzer was the losing pitcher in the Tigers' 5–2 loss in Game 6, the deciding and final game of that series.

On May 5, Scherzer struck out nine Houston Astros batters in eight innings of a 2–0 victory. It was his seventh straight game from the start of the season with at least seven strikeouts, establishing a Detroit Tigers franchise record. The streak ended on May 10 against the Minnesota Twins, when he struck out six batters in six innings. The Major League record for consecutive 7+ strikeout games to start the season is nine, accomplished by Bob Feller in 1946.

On June 12, in his 179th career start, Scherzer consummated both his first career complete game and shutout in a three-hit, 4–0 win versus Chris Sale and the Chicago White Sox. Scherzer struck out eight batters and expended 113 pitches in the contest. It was the longest expanse any major league starter had gone without a complete game since 1900. On 18 previous occasions he had endured at least eight innings, including one for nine that eventually required extra innings to finish, precluding credit for a complete game.

Six days later, Scherzer no-hit the Pirates 6–0 at Nationals Park for his first career no-hitter. After retiring the first 26 batters, he came to within one strike of a perfect game, only to hit the 27th batter, José Tábata, who appeared to lean into the pitch. Scherzer secured the no-hitter by retiring the next batter, Josh Harrison, on a fly ball. This was the 13th time that the 27th and presumably final batter disrupted a perfect game in progress. The game score was 97, the second occasion on the season where Scherzer had achieved a game score of at least 97. It was a feat previously accomplished just twice, first by Nolan Ryan in 1990 and then Pedro Martínez in 2000.

The 100th win of Scherzer's career occurred on June 26 in a 5–2 victory versus the Philadelphia Phillies, where he allowed both runs over eight innings. It was his third consecutive start where he did not allow any baserunners for the first five innings. In June, Scherzer's ERA was 1.79 during which he was named NL Pitcher of the Month for the second consecutive month. Spanning his last three starts of June, he registered 24 consecutive scoreless innings, retired 52 consecutive batters without allowing a hit, struck out 33, and completed 26 of a possible 27 innings.

Over a winless streak of seven starts beginning July 30, Scherzer allowed a 6.08 ERA, seven walks, 11 home runs, a .305/.335/.587 line against and struck out 53 in 40 innings pitched. He earned his 12th win of the season versus Miami on September 14 with eight shutouts innings in a 5–0 win.

Named to his fifth MLB All-Star Game, Scherzer was NL manager Joe Maddon's selection as the squad's starting pitcher, making him the oldest starter in that lineup. He became the fifth pitcher to start at least one All-Star Game for both the American and National Leagues. At the time of his selection, he consolidated a 10–5 record and an NL-leading both of a 2.10 ERA and 173 strikeouts. Played at Marlins Park in Miami, he tossed 15 pitches over one scoreless inning and struck out Aaron Judge and George Springer.

On September 19, Scherzer carried out 250 strikeouts for the fourth consecutive season, phasing into the fourth pitcher in major league history to do so, following Ferguson Jenkins, Randy Johnson, and Pedro Martínez. Scherzer rebounded from an 8–2 loss with seven runs and six walks allowed to Atlanta in his previous start, to strike out seven and with five hits and one walk allowed over seven innings in a 4–2 win, also against Atlanta.

With a 2–0 win over Baltimore on May 30, Scherzer procured career win number 150, while striking out 12 over eight shutout innings. He was named the NL Pitcher of the Month for the month of May—his second consecutive monthly award—after going 4–0 with a 2.21 ERA and a league-leading 63 strikeouts. Entering as a pinch hitter in the 14th inning on June 2 versus the Braves, Scherzer singled for his first career pinch hit and scored the go-ahead run on a triple by Wilmer Difo in a 5–3 victory. In the June 5 contest versus the Tampa Bay Rays, Scherzer settled his second career immaculate inning, striking out Johnny Field, Christian Arroyo and Daniel Robertson in the sixth inning. He advanced into one of five major league pitchers to have recorded more than one in their careers, joining Lefty Grove, Randy Johnson, Nolan Ryan, and Sandy Koufax. Scherzer allowed both runs as earned, five hits, and finished with 13 strikeouts as the Nationals won 4–2, improving his record to 10–1, the first in the major leagues with 10 wins.

On September 25, Scherzer reached 300 strikeouts on the season, striking out Austin Dean of the Miami Marlins in a 10-pitch at-bat in the seventh inning of a 9–4 Nationals win.

On June 18, Scherzer suffered a broken nose after a ball struck him in the face while bunting in batting practice. Nevertheless, he made his scheduled start the next day against the Philadelphia Phillies. With discoloration near his right eye, he threw 117 pitches and struck out 10 Phillies hitters over seven scoreless innings as the Nationals won 2–0. In a start on June 30, he faced his former team, the Detroit Tigers. It was the first time he pitched against Detroit at Comerica Park since joining the Nationals, and first since the 20 strikeout game in 2016. This time, he struck out 14 while allowing four hits over eight innings in a 2–1 win for his 90th career double-digit strikeout game. En route to a historic performance, Scherzer went 6–0 over six starts and 45 innings in June and became the fourth pitcher since 1920 to post an ERA of 1.00 or lower while logging at least 68 strikeouts in one calendar month. It was also the first time since 1908 that any pitcher had struck out at least 68 batters while issuing five or fewer walks in one calendar month. After producing two more games with at least 10 strikeouts and no walks issued, Scherzer had authored 24 such contests, third-most in history. He was named NL Pitcher of the Month for the sixth time.

In Game 2 of the NLCS against the St. Louis Cardinals, one day after teammate Aníbal Sánchez lost his bid for a no-hitter with two outs in the eighth, Scherzer took a no-hitter into the seventh inning before allowing a leadoff single to Paul Goldschmidt. By holding the Cardinals hitless through their first five innings in consecutive postseason games, Sánchez and Scherzer repeated a feat they accomplished in Games 1 and 2 of the 2013 American League Championship Series. No other pair of starting pitchers has ever taken no-hitters into the sixth inning against the same team in consecutive postseason games. Scherzer pitched Games 1 and 7 of the World Series, both in Houston. He was scratched from a planned Game 5 start because of pain in his neck, which required a cortisone shot. Although he struggled in both starts, leaving multiple men on base in most innings, his team got the win in both games. The Nationals won the World Series over the Astros, marking the first championship in franchise history.

With a low three-quarters delivery (nearly sidearm), but with an overarm starting stretch when nobody is on base, Scherzer throws five pitches: a four-seam fastball with good movement averaging 92–96 mph (topping out at 99 mph), a slider at 85–86 mph, a changeup at 84–85 mph, a cutter at 88–89 mph and a curveball at 78–79 mph. He primarily uses a fastball-slider combination against right-handed hitters and a fastball-changeup-cutter combination against left-handed hitters. Occasionally, he also throws a curveball for the first strike in an at-bat.

The Scherzers are socially active. In 2013, they partnered with the Detroit Tigers Foundation on a program called Scherzer's Superstars, in which groups from the Metropolitan Detroit chapter of Big Brothers Big Sisters of America were invited to Comerica Park every Tuesday home game to meet Scherzer and some of his Detroit teammates and go down to the field for batting practice. In 2015, after her husband signed with the Washington Nationals and inspired by the actions of his future teammate Sean Doolittle and Doolittle's future wife, activist and sports journalist Eireann Dolan, Erica May-Scherzer partnered with organizers of the Nationals' annual "Night Out" event for LGBT fans and led an effort by Nationals' spouses to promote the event. May-Scherzer is an ambassador for the Polaris Project, which aims to stop human trafficking; Scherzer started a fundraiser during the Nationals' 2016 season called Strike Out Modern Slavery in which the couple matched donations to Polaris for every strikeout Scherzer threw that season. Both Max and Erica are also involved with the Humane Rescue Alliance, announcing after Hurricane Harvey in August 2017 that they would personally cover all pet adoption fees from the Washington, D.C.-based group's shelters for four days.

The Arizona Diamondbacks chose Scherzer in the first round and 11th overall in the 2006 MLB draft, making him Mizzou's first-ever MLB first-round draft pick. On January 9, 2012, it was announced that Scherzer would be one of six new inductees to the University of Missouri Intercollegiate Athletics Hall of Fame.

On May 20, 2012, Scherzer struck out 15 Pittsburgh Pirates in seven innings, falling one strikeout short of tying Lolich's franchise record. Scherzer surpassed the 200-strikeout mark for the first time, totaling 231 during the regular season to place second in the league to teammate Verlander with 239. Scherzer's strikeout rate per nine innings (11.1) both surged into the double-digit range and led the AL for the first time. He finished the regular season with other then-personal bests in wins and winning percentage (16–7, .696). In four seasons spanning 2009−12, Scherzer went 52−38, 3.94 ERA, 1.302 WHIP, averaging 9.2 strikeouts per nine innings and 191 strikeouts per season.

Despite battling a late-season injury, Scherzer pitched successfully for the Tigers in the 2012 postseason, after they had won the AL Central division. He made three starts, going 1–0 with a 2.08 ERA, while striking out 26 batters over 17​⁄3 innings. The Tigers reached the World Series, for the first of Scherzer's career, and opposed the San Francisco Giants. He started Game 4, yielded three earned runs in 6​⁄3 innings while striking out eight batters, and received a no-decision as the Tigers lost the game in extra innings, 4−3.

Scherzer's younger and only brother, Alex, died by suicide early in the summer of 2012. Alex had a passion for analyzing advanced baseball statistics or sabermetrics. Scherzer learned the value of sabermetrics from his brother, and he implements this as a tool to improve his game. Since Alex's death, Scherzer dedicates every start to his late brother.

In the 2011 season, Scherzer was the third starter in the rotation, and won six straight starts early in the year, being the first Tiger since Jeremy Bonderman in 2006 to accomplish this feat. Scherzer finished the season with a 15–9 record, and was third in the AL in home runs allowed (29), fourth in wild pitches, fifth in hits by pitch (10), ninth in winning percentage (.625), and tenth in wins.

Scherzer has heterochromia iridum; his right eye is blue and his left eye is brown. On June 12, 2011, the Detroit Tigers distributed a bobblehead doll depicting Scherzer, with the condition correctly portrayed. In the spring of 2017, the Nationals unveiled a "delightfully creepy" crop of Scherzer's eyes, correctly portrayed as blue and brown, with backward and forward Ks photoshopped into the pupils.

In Detroit, Scherzer grew from a hard thrower with control issues into an ace, teaming with fellow right-hander and future Cy Young Award-winner Justin Verlander to front the Tigers' starting rotation for five seasons. A third-place finish in 2010 left them out of the playoffs, but was followed by four consecutive AL Central division appearances. This run culminated in winning the 2012 American League (AL) pennant, only to fall to the San Francisco Giants in the World Series.

Scherzer finished the 2010 season with a 12–11 record, 3.50 ERA and 184 strikeouts. Despite spending some time in the minor leagues, his strikeout total was still good for tenth in the American League.

Scherzer became a full-time starter in 2009, filling the fifth starter role in the starting rotation. He recorded his first major league victory in a 12–0 win over the Atlanta Braves on May 16, 2009. On May 26, Scherzer recorded his second win of his career. He finished the 2009 season with 30 starts, a 9–11 record, 4.12 ERA, and 174 strikeouts in 170⅓ innings pitched.

After the 2009 season, Scherzer worked out in Fort Collins, Colorado, with the Colorado State University baseball team.

On December 9, 2009, Arizona traded Scherzer along with Daniel Schlereth, Phil Coke, and Austin Jackson to the Detroit Tigers as part of a three-team agreement that sent Ian Kennedy and Edwin Jackson to the Diamondbacks and Curtis Granderson to the New York Yankees.

On August 1, Scherzer hit his first career home run, a three-run blast off Chris O'Grady of the Marlins, but left the game shortly thereafter with neck spasms. The neck issues recurred, and the club placed Scherzer on the disabled list for the first time since 2009, retroactive to August 15. He was then removed from his next start on August 18 against the San Diego Padres at Petco Park as the neck issue recurred. Scherzer returned to the rotation on August 28, earning a win against the Marlins.

He began playing in the Diamondbacks organization in 2007 with the Single-A Visalia Oaks. He was promoted to Double-A Mobile BayBears after three impressive starts for the Oaks. During the 2008 offseason, he was named the fourth-best prospect in the Diamondbacks organization. After a good start to the 2008 season in Triple-A Tucson he was called up to the Diamondbacks on April 27, 2008.

On April 29, 2008, Scherzer made his MLB debut against the Houston Astros when he came on in relief and threw 4​⁄3 perfect innings while striking out seven. While doing so he set the record for the number of consecutive batters retired (13) for a pitcher making his MLB debut as a reliever. The previous record was 12 set in 1962 by the Los Angeles Dodgers' Pete Richert. The seven strikeouts were one short of the major-league record for most in a debut relief appearance. The Pittsburgh Pirates' Barry Jones had eight on April 20, 1986. On April 30, 2008, the Diamondbacks announced he would be placed into the starting rotation, due to his impressive debut. In his first appearance as a starter for the D-Backs, Scherzer allowed five runs (two earned) in four innings, while striking out five, taking the first loss of his major league career. He returned to the bullpen for much of the 2008 season. He started against the Cardinals on September 24 and lost for the fourth time in his career in a winless season, going five innings, allowing seven hits and four runs (two earned) while walking two and striking out four.

Scherzer participated in the 2008 Arizona Fall League season as member of the Phoenix Desert Dogs.

The Diamondbacks selected Scherzer in the first round and 11th overall of the 2006 amateur draft from the University of Missouri. A seven-time MLB All-Star, he is the fifth pitcher to start an All-Star Game for both the American and National Leagues. He is a winner of three strikeout titles, a four-time wins leader, and a four-time walks plus hits per inning pitched (WHIP) leader. In addition to three Cy Young Awards, he also finished second in its voting in 2018 and fifth in 2014 and 2015. One the most consistent hurlers of his era, he has made at least 30 starts each season from 2009 to 2018, and struck out at least 230 batters in each season from 2012 to 2018. In 2018, he reached 300 strikeouts for the first time. Prior to the 2015 season, Scherzer agreed to a seven-year, $210 million contract with the Nationals, one of the largest in baseball history at its time.

The Arizona Diamondbacks chose Scherzer in the first round with the 11th overall pick of the 2006 MLB draft. Mike Rizzo, the Diamondbacks' scouting director, marveled that Scherzer attacked hitters with a relentlessness that he had never seen. Eight pitchers were selected ahead of him, including Luke Hochevar (first overall pick), Brandon Morrow, Clayton Kershaw, and Tim Lincecum. Scouting reports criticized Scherzer for too violent of a delivery, but Rizzo and other Arizona scouts decided that "the combination of his arm action and his pitching IQ and his attack mode ... we were calling him 'Mad Max' in the draft room. He came at you. He looked angry. He looked mad."

One of Scherzer's coaches at Missouri, Tony Vitello, was tasked with helping to recruit him, and eventually helped him to pitch with more balance and control and to stop leaping at hitters, which frequently caused him to miss up and in to right-handed batters. Ever energetic, in his early baseball career Scherzer exerted so much effort in his windup that his "head whip" constantly caused his cap to fall off. He did not pitch the final 50 days of his freshman season, instead working out and doing long toss, while gaining velocity in the process. Vitello and head coach Tim Jamieson trained him in a drill to balance on his back leg with more coordination and not to fall over his front foot. Scherzer modified it and worked constantly over the following winter, and returned his sophomore year to produce a 1.86 earned run average (ERA) and 131 strikeouts in 106 innings pitched over 16 games. In 2005, he won the Big 12 Pitcher of the Year Award.

Following his freshman year at the University of Missouri, in 2004, Scherzer made his debut with the La Crosse Loggers of the Northwoods League (NWL), a collegiate summer baseball league. He went 2–1 that summer with a 1.91 ERA with six saves. He also struck out 50 batters in only 33 innings pitched. He was named a mid-season All-Star.

Scherzer was born and raised in Chesterfield, Missouri, the son of Jan (Shirck) and Brad Scherzer, and grew up a St. Louis Cardinals fan. He attended and played baseball, football, and basketball at Parkway Central High School in his hometown. Whatever he lacked in raw talent he made up for with the fiercely competitive nature that would distinguish his athletic career. One of his high school coaching influences was basketball coach Rick Kirby, who stressed fundamentals and was defense-oriented. Marty Maier, then the Cardinals' scouting director, was impressed enough to select him in the 43rd round (1,291st overall) of the 2003 Major League Baseball (MLB) draft. However, he did not sign, and instead attended the University of Missouri in Columbia.

Maxwell M. Scherzer (born July 27, 1984) is an American professional baseball pitcher for the Washington Nationals of Major League Baseball (MLB). He made his MLB debut as a member of the Arizona Diamondbacks in 2008, and later played for the Detroit Tigers, prior to joining the Nationals. He has been an important figure in the both the Tigers' and Nationals' playoff presence, including Detroit's four consecutive American League Central titles from 2011 to 2014 and two of Washington's National League East titles, culminating in winning the 2019 World Series as a Wild Card team. A power pitcher with a low three-quarter-arm delivery, Scherzer has achieved numerous strikeout records and distinctions. He is the tenth pitcher in history to garner at least three Cy Young Awards, the sixth to record two no-hitters in one season, the fifth to produce more than one immaculate inning, and the second to strike out at least 200 batters in a season eight years in a row. He is regarded as one of the greatest pitchers of all time.

On October 3, Scherzer achieved his second career no-hitter, and second of the season, versus the Mets, striking out a new career-high 17 batters with no walks. The only base runner permitted was via a throwing error by Yunel Escobar in the sixth inning. Several baseball analysts and pundits debated the game as one of the greatest pitching performances of all time, and perhaps the most dominant no-hitter ever pitched, based on the number of strikeouts, lack of walks issued or hit batters, and sheer mastery of the opposing batting order the third time through the lineup. At one point, Scherzer had struck out nine consecutive Mets, just one shy of the Major League record set by Tom Seaver in 1970. It tied Nolan Ryan for most strikeouts in a no-hitter, was the first no-hitter produced with at least 17 strikeouts and no walks, and made Scherzer the sixth pitcher in MLB history to record multiple no-hitters in one season. With a game score of 104, it was the second-highest achieved on record, and made Scherzer the first to achieve multiple game scores of at least 100 in the same season. That game was singled out for the 2015 Esurance MLB Award for Best Performance.