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In 2012, Mayra Alejandra announced that she had been diagnosed with cancer. She subsequently received chemotherapy treatment, being able to regain a level of normalcy in her life. She suffered a relapse in early 2014, and died in Caracas on April 17 at the age of 55.

Still beautiful at 45, Mayra went back to work in 2000, appearing as a guest star in the Venevisión telenovela Hechizo de Amor. In her later collaborations, she had become typed as a mother, usually playing the parent of grown-up children, appearing as characters that were older than herself, thus acquiring an older image that belied her actual age. Adapting to her new support role, she made significant appearances in Estrambótica Anastasia (2004) and Harina de otro costal (2010), a contemporary and correct version of Shakespeare's Romeo and Juliet.

In the 1990s, she took this time at the height of her popularity to go on sabbatical to take care of her child. Motherhood was part of her public image, and her own children frequently was featured in fan magazine articles and photographs.

Mayra next appeared in another hit, Luisana Mia (1981), but she is best remembered for her strong performance in Leonela (1983), where she played the role of a rape victim falling in love with her rapist. She also appeared in sympathetic parts in Bienvenida Esperanza (1983), Marta y Javier (1983) and La Mujer Prohibida (1991).

In 1978 she portrayed the ill-fated Carmen of Prosper Mérimée, as sensual as unprejudiced, dragged itself to tragedy, in Román Chalbaud's adaptation Carmen la que contaba 16 años.

After attending high school, Mayra made her debut in the Radio Caracas Television telenovela Valentina (1975). Then, her first starring role was in Angélica (1976), where she played a character created especially designed for her by her mother Ligia Lezama. Later, the young actress excelled in La hija de Juana Crespo (1977), an effective drama from Salvador Garmendia and José Ignacio Cabrujas.

Mayra Alejandra [my'rah / aleh-han'-drah] (May 7, 1958 – April 17, 2014) was a Venezuelan television and film actress.