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Mwaura has led sustained campaigns against stigmatization, discrimination, violence and persecution of persons with albinism in Kenya and East Africa. Mwaura attributes this plight facing persons with albinism to ignorance, myths and superstitions surrounding albinism. Fallacies and misconceived ideas about promise of wealth, health and success have led to kidnapping, trafficking and brutal murder of innocent men, women and children. “The threat to persons with albinism in Kenya, and East Africa is very real," said Mwaura in 2015 after rescuing Robinson Mukwana, a young male Kenyan with albinism who had been lured to Tanzania on the promise of a job only to be presented to willing buyers. Mwaura, who adopted and educates two young children with albinism - Bianca Chacha and Gabriel Kinyanjui - who had been abducted for ritual killings in 2016 but salvaged, appealed to the East Africa Community. "The heads of state from East Africa should come up with a policy statement on the plight of persons with albinism in the region which has reached alarming levels." Mwaura says that persons with albinism continue to face threats of their lives. Over 600 persons with albinism have been ritually killed in Africa, with Tanzania leading with 76 reported deaths. In August 2019, a teenage boy with albinism was killed and his body mutilated in Burundi, while in South Africa, a 40-year old teacher in August 2019 admitted guilt to kidnapping and killing a 13-year-old girl with albinism, Gabisile Shabane, for ritual purposes. Mwaura has associated these killings to election cycles or drought and famine in Africa. Mwaura, in a press conference in Nairobi on 24 August 2019 apportioned blame to heads of state in Africa for their passivity and failure in safeguarding rights and freedoms of persons with albinism. Mwaura asked, "How comes that Africa, which suffered from many years of slavery, is the same that is leading in the killings of Persons with Albinism and discrimination based on skin colour?"

Mwaura also observes that persons with albinism in Africa lack a true identity as 'they are neither black nor white enough.' Mwaura said in 2019, "We continue to suffer from 'in betweenness' - white but not white enough, black but not black enough, disabled but not disabled enough." Derogatory labels such as zeruzeru (meaning ghost), nguruwe (pig) and dili (which literally means ‘deal’, and refers to the trade of the body parts of people with albinism on the black market) are used to refer to persons with albinism in East Africa while among the Yoruba and Hausa of Nigeria they are referred to as Afin or eni-orisa (one who belongs to the deity) and Bature-Ntuda, meaning fake white person respectively. Organisations such as Albinism Society of Kenya (ASK) have been established to create awareness about albinism and to fight for all forms of discrimination and persecution targeting persons with albinism. A 2009 Kenyan documentary, In My Genes, directed and produced by Lupita Nyong'o, communicates strongly the plight of persons with albinism.

Forums such as International Albinism Awareness Day and Mr and Miss Albinism East Africa pageantry have strengthened the group identity of persons with albinism. Also, United Nations has ensured inclusion of albinism agenda in their human rights framework by appointing Ms. Ikponwosa Ero, a woman with albinism, as the first Independent Expert on the enjoyment of human rights by persons with albinism. The mandate of this office includes raising awareness on the rights of persons with albinism and to combat stereotypes, prejudices and harmful traditional practices and beliefs that hinder their enjoyment of human rights and participation in society on equal basis with others, among other functions. In 2019, Mwaura led a team of Africans with Albinism to the Africa Union's Council of Ministers in Addis Ababa, Ethiopia, where Africa Union Action Plan on Albinism was adopted and a position of a Special Envoy on Albinism established.

On a Facebook post, Mwaura reported about being harassed and discriminated by virtue of his albinism by the Secret Service agents during a UN General Assembly forum in New York in September, 2019. “I get into the building and check in at the security. I do the usual stuff of emptying my pockets, then I go through the machine and they do a body search. Then I'm told to step aside and I am kept waiting for over thirty minutes. The Secret Service agents ask for my ID and by this time, they have picked my entry card.” Mwaura was informed by the Secret Service that they looking for someone who fitted his description and who was walking around with a screwdriver. Mwaura wondered, ‘In the US, people are allowed to own and carry guns, and here we are talking about a screwdriver?’ Mwaura was again to suffer more humiliation in the same event as he was initially denied access to meet President Uhuru Kenyatta and other colleagues at Hotel Latte. ‘The Secret Service takes my card again while others start taking photos of me secretly with their phones...’ Even with Mwaura’s colleagues explaining that Mwaura was a senator from Kenya, the Secret Service still followed him into the lift while looking at him suspiciously. Mwaura then suffered the same treatment as he was denied access to his hotel room despite providing his UN accreditation. Mwaura said he could not endure the harassment any further and reminded a secret service agent he was ‘a person of colour’ and a senator from Kenya when he inquired if Mwaura was a US senator. Later, US Ambassador to Kenya Kyle McCarter offered apologies to Mwaura for the incidences.

In 2018, Mwaura through ASK, organised the first ever Mr and Miss Albinism East Africa pageantry in Nairobi with its theme 'Beauty Beyond the Skin'. The contest which aimed at showcasing talents of youth with albinism and to combat stigma and discrimination, brought together 30 contestants drawn form Kenya, Uganda and Tanzania.

At parliament level where he is a Senator, Mwaura has successfully championed for the increase in budget allocation to National Council for Persons with Disabilities, as well as inclusion of youth with disabilities to the National Youth Service. Besides advocating for persons with disabilities to be appointed to various constitutional commissions and government agencies, Mwaura has ensured an establishment of an isolated budget to cater for free sunscreen lotions skin cancer treatment and eye-care services for persons with albinism. Mwaura is the pioneer and the founding chair of Kenya Disability Parliamentary Association (KEDIPA), a caucus of Members of Parliament with disabilities in Kenya. Furthermore, Mwaura in 2018 petitioned Central Bank of Kenya to ensure the new currency is accessible to persons with visual impairments, which was adopted and implemented. Also, Mwaura successfully lobbied and pushed amendments to the law to have persons with albinism captured in the 2019 Census in Kenya as well as enumeration of intersex persons.

Finally, availability of data is seen as important approach to strengthening identity of persons with albinism. Many countries in Africa are yet to have official data on persons with albinism. Only in Malawi in 2018 that enumerated and published figures of persons with albinism at 134,000 against a previously estimated figure of 17,000. This case in Malawi indicates there could be a higher prevalence of persons with albinism globally and more so in Africa. Albinism Society of Kenya estimates a figure of between 10,000 and 30,000 persons with albinism in Kenya, but these figures are unverifiable until census with enumeration of persons with albinism is conducted. In his capacity as a Senator for Persons with Albinism, Mwaura has pushed for the inclusion of persons with albinism in 2019 Kenya Census.

Mwaura thereafter joined Uhuru Kenyatta's presidential campaign team as one of the chief campaigners and a strategist. He was nominated as a Senator by Jubilee Party in 2017 to represent Persons with Disabilities in the Senate.

In 2016, Mwaura was honoured with the First Class: Chief of the Burning Spear (CBS) by Kenya's President Uhuru Kenyatta for his immense disability advocacy and parliamentary achievement. Similarly, in 2019, Mwaura was feted during the United Nation's 40th Human Rights Council Convention in Geneva, Switzerland for his efforts in fighting for the rights of persons with albinism in Kenya.

In 2016, Mwaura ditched Orange Democratic Movement party and joined Jubilee Party. In April 2017, he participated in Jubilee Party primaries as a candidate for Ruiru Constituency Parliamentary seat where he was politically nicknamed as 'Muthungu wa Ruiru' or the white man from Ruiru, but did not secure the party nomination. Mwaura termed primaries as 'not credible' as the party primaries across the country were marred with disorganization, rigging, voter bribery, violence and chaos. Two days before the primaries, Mwaura and his political competitor Simon King'ara had been involved in altercation when Mwaura went to stop demolition of a motor bike shade he had constructed. Chaos ensued and gun shots rang in the air, leaving Mwaura with an injury on his ear. Mwaura immediately reported it as an assassination attempt and that a bullet had grazed his ear. Nevertheless, Mwaura conceded defeat, stating that his political debut had 'helped fight stigma and discrimination, break glass ceiling, push the awareness and inclusion agenda forward, and inspire many other people in Kenya and beyond to stand up and be counted."

Mwaura in 2014 stated that persons with albinism in Kenya used the ambiguities in law to fight for recognition and their rights as citizens and pointed that the state ought to recognise threats to their lives as an infringement of their rights and grant them protection. Although Mwaura and Albinism Society of Kenya have successfully lobbied for a state-funded national sunscreen distribution programme for all registered persons with albinism in Kenya, the programme's current success and future sustenance seems dependent on the presentation of albinism as a disability, both in physiological as well as legal terms. Pushing for the political recognition of people with albinism, both as individuals with a disability and at the same time as persons who should be fully included in society (through inclusive education and equal job market opportunities), is one of the positions that Mwaura and organisations such as Albinism Society of Kenya are carrying forward.

However, Mwaura courted attention and controversy in February 2014 during the Orange Democratic Movement party National Delegates Convention in Kasarani Gymnasium in Nairobi during the election of party officials. The voting was proceeding on peacefully until when Mwaura sprang to a table to protest against omission of his name from ballot papers. Chaos erupted and an ambush of mafia-like men in black suits, infamously referred as 'men-in-black', stormed the gymnasium and destroyed ballot papers and boxes. Delegates scampered out of the hall and the voting ended abruptly.

Mwaura Isaac Maigua is a Kenyan politician, a disability advocate and currently a Nominated Senator in the Kenya's Senate, representing Persons with Disabilities. He is the first Member of Parliament (MP) in Kenya with Albinism. He belongs to Jubilee Party. Previously he was a Member of Parliament (MP) in the National Assembly (between 2013 and 2017) after having been nominated by the Orange Democratic Movement Party to represents Special Interest Groups. Mwaura served as a Senior Adviser to former Prime Minister Raila Odinga from 2010 to 2012 on Public Policy on Special Interest Groups.

Mwaura points prejudice and superstition about albinism as the most prevalent challenge that persons with albinism experience: “You find people don't want to shake your hand – they think albinism is contagious,” he said. “and people don't realise when they are doing it, but I can notice. They shake your hand, then they kind of try to wipe it off.”

In 2013, Mwaura was nominated by Orange Democratic Movement as a Member of Parliament (MP) in the Kenya's National Assembly to represent Special Interest Groups and he made history as the first Member of Parliament with albinism in Kenya.

Mwaura has distinguished himself as a brilliant debater, both in Parliament and on the media and has been rated as one of the best performing Members of Parliament. He is fluent in English, French, Swahili and Kikuyu and is an author of the book: A Discourse of Human Rights, Disability and Development in Kenya (2009).

Mwaura featured in In My Genes, a Kenyan 2009 documentary film that was directed, written, produced and edited by the award-winning actress Lupita Nyong'o in her directing debut. The documentary, where Mwaura acted as an aspiring politician (a screen dream that he has fulfilled), highlights the plight of persons with albinism. Mwaura had met Lupita in 2006, and through this encounter, she introduced him to her father, Professor Peter Anyang' Nyong'o, the governor of Kisumu County, who later became his political mentor and the first patron of Albinism Society of Kenya.

In 2006, Mwaura and other persons with albinism in Kenya founded Albinism Society of Kenya (ASK), a national organisation that bring together persons with albinism in Kenya and whose mission is to create awareness on the rights of persons with albinism, their social inclusion, empowerment and equity to socio-economic opportunities. Mwaura articulated the objective of ASK: "We wanted to share and celebrate our differences and uniqueness as persons with albinism and lobby the government to fund the national development fund for persons with albinism.” Mwaura is the National Coordinator and the Chairman of Albinism Society of Kenya, and through his stewardship, the organisation has made significant milestones in rescuing persons with albinism from ritual killings as well as creating job opportunities and economic empowerment for persons with albinism in Kenya. Additionally, the organisation has been involved in policy and legislative advocacy, albinism awareness, eye-care and sunscreen programme, education support, counselling programme and cancer treatment intervention for persons with albinism . Through ASK, persons with albinism in Kenya are provided with free sunscreen lotions, prescription glasses and protective clothing in order to shield them from harmful solar radiation. Also to note, more than 30 hospitals in Kenya have been equipped with cryotherapy equipment in order to assist in mitigation of skin cancer, and a special fund has been set aside to meet medical expenses of skin cancer sufferers with albinism. Other key achievements ASK is proud of is the appointment of Mumbi Ngugi, a woman with albinism, as the Judge of High Court in Kenya and emergence of Goldalyn Kakuya, a girl with albinism, as the best student in the Kenya Certificate of Primary Education in Kenya in 2017 after scoring 455 marks out of 500. Mwaura has mentored young persons with albinism, including Martin Pepela Wanyonyi, an elected Member of County Assembly (MCA) for Ndivisi Ward in Bungoma county, and Timothy Aseke who is a nominated MCA in Kakamega county.

After completing his undergraduate course at Kenyatta University, Mwaura joined Orange Democratic Movement (ODM) party as a member in 2006 and rose ranks to become the Secretary of Disability Affairs. During 2007 Kenya's General election, Mwaura was instrumental in mobilizing voters with disabilities and campaigning for the ODM presidential candidate Raila Odinga. After the 2007-2008 Kenyan crisis that resulted in the formation of Government of National Unity with Mwai Kibaki as a President and Raila Odinga as a Prime Minister, Mwaura was appointed as a Senior Adviser on Special Interest Groups in the Prime Minister's office and served from 2010 to 2012.

Mwaura has worked in different organisations, both nationally and internationally. In 2004, while still a university student and aged 22 years, Mwaura was appointed as a board director to the National Council for the Persons with Disabilities, making him the first youngest board member in Kenya. After graduating from Kenyatta University in 2006, Mwaura worked as a Regional Programme Coordinator (Gender and Youth Development) with African Union of the Blind as well as a Programme Officer and Programme Manager with United Disabled People of Kenya and Kenya Society for the Blind respectively. He then joined National Council for Persons with Disabilities (NCPWD) as the Head of Communications and Public Relations before rising to the position of Deputy Director of Programmes in the same state agency. He left the council in 2007 and joined Uraia Trust Civic Education Programme as a programme Officer in charge of the National Civic Education Programme. Mwaura joined Voluntary Services Overseas and worked as a Programme Development Advisor on Human Rights Based Approach in Papua New Guinea before jetting back to Kenya to work as a Senior Adviser on Special Interest Groups to the former Prime Minister of Kenya Raila Odinga.

Though the definition of albinism as a disability in Kenya is within the implicit scope of 'visual and physical impairment...' (Persons with Disabilities Act, 2003), Mwaura in his capacity as a Member of Parliament (MP) has come up with an amendment to the Act (The Persons with Disabilities Bill, 2019) to secure a distinct and explicit identity of albinism as disability in the law.

Mwaura's political career commenced in Kenyatta University where he was elected as a student leader in 2002 when he was a freshman. Through this position, he joined hands with other elected student leaders and lecturers to lobby the President Mwai Kibaki's Narc government to grant amnesty and readmit university students who had been expelled during the President Daniel arap Moi's regime. Subsequently, he and other leaders organised a major strike that ousted the Vice-Chancellor Professor George Eshiwani who was serving an illegal term at Kenyatta University.

After completing his Kenya Certificate of Secondary Education in 2000, Mwaura joined Kenyatta University in 2002 for a bachelor's degree in Special Education, French Studies and Japanese and completed in 2006. He further pursued and completed a Post-graduate diploma in Public Relations Management in Kenya Institute of Management and a Diploma in Theology in Presbyterian University of East Africa. Between 2010 and 2012, Mwaura enrolled and graduated with two master's degree: Master's Degree in Social and Public Policy as a Ford Scholar from University of Leeds in United Kingdom and Masters in Arts in Development Studies from Nelson Mandela Metropolitan University in South Africa. In 2016, Mwaura was conferred with an honorary Doctor of Philosophy in Humanities (Honoris Causa) from UGCI- USA for his immeasurable contribution in serving the marginalized and minorities in Kenya.

Mwaura went through schooling and emerged the top pupil in the Kenya Certificate of Primary Education (KCPE) in his school in 1996. He won a slot in Starehe Boys' Centre, a prestigious and the top-performing school in Nairobi, but instead he opted for Thika High School of Blind which he joined in 1997. While at high school, Mwaura became the school's head boy, an opportunity that enhanced his leadership skills.

Mwaura was born in Githunguri, Kiambu County in 1982 and was solely raised by his mother, Grace Mwaura, after his father disowned him and divorced Grace after Mwaura was born with albinism. The deserted family relocated to Mwaura's maternal grandmother where he and his elder brother grew up. "My father said very nasty things to my mother and declared that in his family they don't get such kids. He even accused her of being unfaithful, and that she had conceived me with some somebody of Causian or Asian origin." Mwaura said in 2014 in a media interview.