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As of 2016, Stryker ranks #264 on the Forbes Women 400.

Stryker donated $1.5 million to Priorities USA Action, a Super PAC supporting Democratic presidential candidate Hillary Clinton in 2016. She was among the largest donors in the 2016 election.

In 2008, Stryker gave $87,500 to the Presidential Inaugural Committee for President-Elect Barack Obama.

In 2006, Stryker gave $500,000 to the Coalition for Progress, a political action committee that donated heavily to support Democratic party candidates in Michigan elections.

According to New York Times reporter Matt Bai, Stryker attended the April 2005 meeting of the Democracy Alliance near Scottsdale, Arizona. Stryker along with George Soros and other Democracy Alliance members Gail Furman; Paul Rudd (co-founder of Adaptive Analytics); John R. Hunting; Nicholas Hanauer; ex-Clinton administration official Rob Stein; Drummond Pike; real estate developer Robert Bowditch; Pioneer Hybrid International-heir and congressional candidate Scott Wallace; Susie Tompkins Buell; real estate developer Albert Dwoskin; and Taco Bell-heir Rob McKay, funded the Secretary of State Project, an American non-profit organisation, 527 political action committee focused on electing reform-minded progressive Secretaries of State in battleground states, who typically oversee the election process. The Alliance was critical in getting California Secretary of State Debra Bowen and Minnesota Secretary of State Mark Ritchie re-elected.

Stryker donated $3 million to defeat a 2002 ballot initiative regarding bilingual education in Colorado.

Since the early 2000s, she has become more active in civic life. In 2001, she founded the Bohemian Foundation, which focuses on music, arts and the community through grantmaking, programs, and events. She donated $3 million to defeat a 2002 ballot initiative regarding bilingual education in Colorado. In 2004, she gave $20 million to Colorado State University, mostly to benefit its football team.

Stryker bought Sonoma's Sommer Vineyards in 1999, which she rebuilt, replanted, and rechristened as Stryker Sonoma. It covers 32 acres (129,000 m²) in Alexander Valley, California, producer of classic vinifera varieties Bordeaux and Zinfandel. In May 2016, she sold the winery to focus on her foundation work.

Patricia A. Stryker (born 1956) is an American billionaire businessperson, philanthropist, and political activist. Stryker is the granddaughter of Homer Stryker, founder of Stryker Corporation, a medical technology company.