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The duo wrote Tim Burton's 2014 film Big Eyes, a biopic about painter Margaret Keane. They were slated to direct, but vacated later. They were also set to collaborate with Burton on a new stop-motion The Addams Family film, but the project was scrapped in 2013.

In 2014, the team began working on their first television series, American Crime Story, which is a true crime anthology drama. The first season is based on the O. J. Simpson trial. The show won four Primetime Emmys after it aired on FX in 2016, with Alexander and Karaszewski nominated for Outstanding Writing for a Limited Series, Movie, or Dramatic Special.

In 2007, they both appeared in the documentary Dreams on Spec, a film looking at the Hollywood creative process from the perspective of the writer.

In 1994, Alexander and Karaszewski persuaded Tim Burton to direct a biopic about Edward D. Wood, Jr., titled Ed Wood. They wrote the screenplay in six weeks.

Their first success was the popular but critically derided comedy Problem Child (1990). Alexander and Karaszewski claim that their original screenplay was a sophisticated black comedy, but that the studio watered it down into an unrecognizable state.

Scott Alexander (born June 16, 1963, Los Angeles, California) and Larry Karaszewski (/ˌ k ær ə ˈ zj uː s k i / ; born November 20, 1961, South Bend, Indiana) are an American screenwriting team. They met at the University of Southern California where they were roommates; they graduated from the School of Cinematic Arts in 1985.