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Neumeier supported the FDA's ban of electric shock devices in 2020 at the Judge Rotenberg Center, but said that the government must find other options for those affected.

In 2019, University of Portsmouth psychology professor Dr. Steven K. Kapp wrote, "Shain Neumeier and Lydia Brown [...] have taken leading roles in activism to stop the electric use of shocks as 'treatment', raising the profile of the issue and providing strong legal and ethical arguments that have assisted progress toward banning the tortuous practice."

In 2019, Neumeier co-authored an article describe their and Lydia Brown's advocacy work against the Judge Rotenberg Center for a collection of essays titled Autistic Community and the Neurodiversity Movement: Stories from the Frontline.

In Neumeier's essay for disability rights activist Alice Wong's 2018 collection Resistance and Hope: Essays by Disabled People, they describe life in the U.S. under the Trump administration as creating a "culture of abuse" and relying on a form of social Darwinism that praises strength and vilifies perceived weakness, such as desire for safe spaces. Neumeier argues that many disabled activists take up advocacy because they have experienced trauma and lack of safety, and so choose "to go back into the fires that forged us again and again to pull the rest of us out, and to eventually put the fires out altogether."

As an advocate in the neurodiversity and transgender rights movements, Neumeier has spoken at conferences including the annual Rebellious Lawyering Conference at Yale Law School, Creating Change, the Autism National Committee, Brandeis University's DEIS Impact Roundtable for Social Justice, the inaugural Disability Intersectionality Summit in Boston, and the Georgetown University Lecture and Performance Series on Disability Justice. In August 2017, Neumeier delivered the keynote address at the National Empowerment Center's Alternatives Conference for consumers and peers with mental health disabilities. Neumeier also gave the keynote for the 2019 Mad Pride celebration organized by Vermont Psychiatric Survivors, and for the 2019 Autism National Committee conference.

Neumeier received the Leadership in Advocacy Award from the Association of University Centers on Disabilities in 2015. Later, in 2018, Neumeier received the Outstanding Young Lawyer of the Year Award from the Massachusetts Bar Association.

Neumeier published a series of seven articles for the Autistic Self Advocacy Network about the trial testimony, including an account of the first instance that video of the electric skin shocks was made available for public viewing. Neumeier also testified at the U.S. Food and Drug Administration's 2014 public hearing on a proposal to ban electric shock treatments for behavioral modification of people with developmental disabilities. In 2016, Neumeier published an op-ed in USA Today calling for a final ban on the electric shock aversives. Neumeier opposes use of electric skin shock aversive treatment as a form of torture, and believes its use is connected to the behavioral modification goals of applied behavior analysis, a widely used form of early intervention treatment for autism.

In December 2013, upon invitation by the United Nations Special Rapporteur on Torture, Neumeier joined CAFETY's Executive Director Kathryn Whitehead for an expert consultation meeting hosted at the Center for Human Rights and Humanitarian Law on torture and other cruel, inhuman, or degrading treatment in health-care settings with international human rights organizations, and delivered a presentation on systemic patterns of abuses in youth residential treatment programs, which CAFETY refers to as the troubled teen industry.

In 2012, Neumeier attended and reported extensively on a medical malpractice trial against the Judge Rotenberg Center brought by former resident Andre McCollins, who received 31 shocks over a period of six hours. Neumeier also testified before the United Nations Special Rapporteur on Torture about the Judge Rotenberg Center.

Shain Mahaffey Neumeier (born 1987) is an American autistic and nonbinary transgender activist and attorney from Los Angeles, California. An activist for disability rights, youth liberation, asexuality, and transgender rights, Neumeier was diagnosed as autistic in 2010 while a law student. They also have other disabilities including depression, post-traumatic stress disorder, cleft lip and palate, and ectodermal dysplasia.

Neumeier's father is screenwriter Edward Neumeier, known for co-writing the 1987 film RoboCop.