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White's more than 500 publications in the refereed professional literature have been cited more than 168,000 times by other scientists (status end-2018 according to Google Scholar).

Work by White has addressed issues of stellar dynamics, of the detailed structure of galaxies and their dark halos, of the processes controlling galaxy formation, of the structure and evolution of galaxy clusters, and of the statistics of galaxy clustering. Papers include those with Julio Navarro and Carlos Frenk on the "universal" structure of dark matter halos. The Navarro–Frenk–White profile is named after them.

In later years White developed computer models which allowed the growth of galaxies and galaxy clustering to be simulated directly in order to allow quantitative comparison of theoretical models with astronomical observations. His work with Marc Davis, George Efstathiou and Carlos Frenk was particularly influential in establishing that a universe dominated by Cold Dark Matter could produce large-scale structure in the galaxy distribution which closely resembles that observed. A more recent large project was the Millennium Simulation, carried out in Garching in 2005 as part of the work of a large international collaboration, the Virgo Consortium. This simulation followed the formation of more than 2,000,000 galaxies throughout a cubic region more than 2 billion light-years on a side.

Already at the time of his doctoral work he studied the influence of Dark Matter on the growth of structure and in 1978 he and Martin Rees argued that the properties of galaxies can be understood if they form by condensation of gas at the centres of extended and hierarchically clustering dark matter halos.

White studied Mathematics at Jesus College, Cambridge in the University of Cambridge (B.A. 1972) and Astronomy at the University of Toronto (M.Sc. 1974). In 1977 he obtained a doctorate in Astronomy under Donald Lynden-Bell entitled "The Clustering of Galaxies" at the University of Cambridge. After a few years at the University of California, Berkeley, the Steward Observatory of the University of Arizona and the University of Cambridge he was appointed in 1994 as a Scientific Member of the Max Planck Society and as Director of the Max Planck Institute for Astrophysics in Garching. White is also Research Professor at the University of Arizona (1992), Guest Professor at the University of Durham (1995) Honorary Professor at the Ludwig-Maximilians University in Munich (1994) and at the Astronomical Observatories of Shanghai (SHAO) (1999) and Beijing (BAO) (2001). White lives in Munich with his wife, the astrophysicist Guinevere Kauffmann, and their son Jonathan.

Simon David Manton White (born 30 September 1951), FRS, is a British astrophysicist. He was one of directors at the Max Planck Institute for Astrophysics before his retirement in late 2019.