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At Harvard, Tadesse maintained a B average grade—too low for admittance to Harvard Medical School, but likely high enough to get into other good medical schools. She made no friends, remaining distant even from relatives she had in the area. Tadesse sent a form letter to dozens of strangers that she picked from the phone book, describing her unhappiness and pleading with them to be her friend. One woman responded to the letter but became alarmed by the bizarre writings and recordings Tadesse sent her in return; she had no further contact with Tadesse. Another woman found the letter obnoxious and sent it to a friend who worked at Harvard to review.

Trang Ho's family thought Harvard could have prevented her death. In 1998, they filed suit against the school, alleging "wrongful death, conscious pain and suffering and emotional distress," and charging the university, as well as various people in charge at Dunster House, with negligence. They felt that the university had plenty of evidence that Tadesse was losing her mind and becoming fixated on violent vengeance, and that the university could have prevented the deaths.

In 1997, Melanie Thernstrom, who had graduated from Harvard in 1987 and taught creative writing there, published a nonfiction book about the case and its aftermath, Halfway Heaven: Diary of a Harvard Murder, which was sharply critical of how Harvard handled the crime. She also detailed several instances of Harvard students with mental health issues having their situations exacerbated by unsympathetic university officials and ineffective advisors.

On May 28, 1995, Tadesse stabbed her roommate Ho 45 times with a hunting knife, killing her. Tadesse also attacked one of Ho's visiting friends, a 26-year-old named Thao Nguyen, severely injuring her as well. Tadesse then hanged herself in the bathroom.

Sinedu Tadesse (September 25, 1975 – May 28, 1995) was a junior at Harvard College who stabbed her roommate, Trang Phuong Ho, to death, then committed suicide. The incident may have resulted in a variety of changes to the administration of living conditions at Harvard. Tadesse is buried at the Ethiopian Orthodox Cemetery, Addis Ababa, Ethiopia.