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By 2017, The Resource Group was operating as an equity vehicle with a number of subsidiaries, for example the offshore company TRG International. It primarily invested in "business process outsourcing (BPO) and related technology companies," according to Chishti. By 2018, Chishti was a named inventor on around 150 issued patents and had founded three unicorn companies. He was awarded the Sitara-e-Imtiaz Award for IT by Pakistani President Mamnoon Hussain in March 2018. That April, Chishti was also a recipient of the MIT AI Innovator Award.

In 2005, Chishti and several former Align Technology employees founded the medical device company Orthoclear. The company settled a patent infringement lawsuit filed by Align in 2006, with Align purchasing Orthoclear's intellectual property for $20 million. Chishti subsequently returned his attention to TRG.

In 2005 Chishti founded Afiniti in Washington, D.C., with TRG holding approximately half of the startup's stock. Serving as CEO and chairman, Chishti wrote the first draft of Afiniti's software on his dining room table in 2006. The product uses artificial intelligence to help companies increase call center. efficiency. Afiniti had a valuation of $1.6 billion by 2017 and was considered a unicorn, which are companies valued at over $1 billion. Chishti continued to serve as Afiniti's CEO and chairman of the board, which also included directors such as John W. Snow and José Maria Aznar.

After leaving Align Technology, Chishti became the founding chairman and CEO of The Resource Group (TRG). As his first acquisition with TRG, he purchased the Pakistani operations of Align Technology in Lahore, which Align had shed in 2001. Chishti "took the abandoned office filled with laid-off workers and asked them to trust his vision for a call-center empire." Chishti listed TRG on the Karachi Stock Exchange in July 2003. By 2005, the company had operations in Karachi and Lahore and was supporting and acquiring American call centers.

In July 2001, People Magazine listed Chishti among the top 50 bachelors in the United States. Chishti works out of Washington, D.C. He is an avid chess player and skier.

After starting his career as a Morgan Stanley investment banker, Chishti invented the medical device Invisalign and co-founded Align Technology to market the product in 1997. He served as CEO of Align until 2003, when he founded the investment fund The Resource Group. In 2005 he co-founded both Orthoclear and Afiniti, the latter of which develops artificial intelligence for use in customer call centers. Chishti was a named inventor on around 150 issued patents by 2018, and had co-founded three unicorn startup companies.

Chishti subsequently became an investment banker at Morgan Stanley, working in New York and London, England on mergers and acquisitions. He also worked for McKinsey & Company as a management consultant in London. In 1997 he graduated from Stanford University in California with an MBA.

Undergoing a course of orthodontic treatment in his early twenties, Chishti envisioned clear plastic appliances instead of metal braces. Working on the project in his dorm room at Stanford University, his invention, Invisalign, allowed computers to customize plastic retainers to gradually shift patient's teeth. Serving as founding CEO and chairman, in 1997 he co-founded the medical device company Align Technology in Sunnyvale, California. The Food and Drug Administration granted Align Technology approval to sell and market Invisalign in 1998. Chishti secured funding from Kleiner Perkins Caulfield & Byers, and the company had raised around $140 million in venture capital by 2000. Align Technology listed on the NASDAQ in January 2001 with a valuation of $1 billion. Chishti left Align Technology in 2003 and sold his shares in the company.

Muhammad Ziaullah Khan Chishti (born 1971) is a Pakistani–American investor and business executive. He is the founder of Afiniti and TRG Global.

Zia Chishti was born as Wilson Lear in 1971 in Bar Harbor, Maine. His father was American and his mother Pakistani, and after the death of his father in 1974, he and his mother moved to Lahore, Pakistan. At that time, his name was legally changed to Zia Chishti. Although Chishti intended to pursue a business career in Pakistan after graduating from the Lahore American School, he was persuaded by his mother to return to the United States. In 1988 he moved to New York City to begin attending Columbia University, where he earned a BA in computer science and economics in 1992.